NHS-AS1

Across TCGA pan-cancer cohorts, NHS-AS1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of NHS-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where NHS-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types NHS-AS1 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, LUAD, and LUSC are the cancer types where NHS-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NHS-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−0.814	<.001	10	view →
LUAD	All	III,IV	+0.232	.004	5	view →
LUSC	Female	All	+0.314	.001	4	view →
COAD	All	All	+0.057	.015	4	view →
KIRP	Male	All	+0.755	.001	3	view →
STAD	Female	III,IV	+0.380	.010	3	view →
THCA	All	All	−0.118	<.001	3	view →
PAAD	All	All	+0.395	.014	2	view →
UCEC	All	III,IV	−0.248	.046	2	view →
HNSC	All	II,III,IV	−0.033	.039	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

NHS-AS1–KICH

Open the KICH breakdown →