NHP2

Across TCGA cell cohorts, NHP2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,992 significant associations in total. PANCREAS shows the largest number of these associations.

The most reproducible NHP2-associated GO terms across cancer lineages are rRNA metabolic process, U4 snRNA 3'-end processing, and rRNA processing. Each is linked with NHP2 in more than 16 cancer types. Because this analysis shows association rather than direction, both NHP2-to-partner and partner-to-NHP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, rRNA metabolic process grouped by NHP2-low versus NHP2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NHP2→partner) and Y-score (partner→NHP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	rRNA metabolic process →	+0.169	+1.066	<.001	<.001	3	16
URINARY_TRACT	U4 snRNA 3'-end processing →	+0.132	+0.877	.004	<.001	2	17
BONE	rRNA processing →	+0.180	+1.061	<.001	<.001	3	16
BONE	Pseudouridine synthesis →	+0.156	+1.078	<.001	<.001	3	15
BONE	Nucleolar large rRNA transcription by RNA polymerase I →	+0.180	+1.244	<.001	<.001	3	15
BONE	Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.177	+0.771	<.001	.003	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,992 associations by consensus.

rRNA metabolic process by NHP2 expression — BONE

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