Across TCGA patient cohorts, NHLRC1 mutation is significantly associated with the RNA expression of many other genes, with 342 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NHLRC1-associated genes across cancer lineages are RNA5SP411, RNU6-648P, and RNA5SP422. Each is linked with NHLRC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NHLRC1-to-partner and partner-to-NHLRC1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NHLRC1→partner) and Y-score (partner→NHLRC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP411 →	+1.545	+2.171	<.001	.009	3	2
BRCA	RNU6-648P →	+0.262	+8.055	<.001	.007	3	2
UCEC	RNA5SP422 →	+1.152	+2.448	<.001	.004	3	2
UCEC	RNA5SP423 →	+1.239	+2.495	<.001	.003	3	2
BLCA	RNU6-588P →	+0.334	+3.914	<.001	.002	3	2
BLCA	CHEK2P5 →	+0.322	+4.296	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 342 associations by consensus.

Exploration

NHLRC1 survival (RNA) · tumor vs normal (RNA) · all NHLRC1 data types