NGRN

Across TCGA cell cohorts, NGRN mutation is significantly associated with the drug of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NGRN-associated genes across cancer lineages are VE-822, 630600, and JAK1_8709. Each is linked with NGRN in more than 1 cancer types. Because this analysis shows association rather than direction, both NGRN-to-partner and partner-to-NGRN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VE-822 grouped by NGRN-low versus NGRN-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NGRN→partner) and Y-score (partner→NGRN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	VE-822 →	+0.596	+2.646	.038	.047	3	1
LARGE_INTESTINE	630600 →	+0.643	+2.649	.039	.046	3	1
LARGE_INTESTINE	JAK1_8709 →	+0.491	+2.649	.012	.046	2	1
LARGE_INTESTINE	SU11274 →	+0.434	+2.652	.037	.045	2	1
LARGE_INTESTINE	AZD7762 →	+0.662	+2.646	.008	.047	1	1
LARGE_INTESTINE	Dinaciclib →	+0.521	+2.646	.043	.047	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

VE-822 by NGRN expression — LARGE_INTESTINE

Explore this box plot interactively →