NGRN

Across TCGA pan-cancer cohorts, NGRN RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of NGRN’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where NGRN RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NGRN is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, THCA, and KICH are the cancer types where NGRN tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NGRN RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.720	<.001	10	view →
THCA	All	II,III,IV	−0.561	<.001	10	view →
KICH	Male	All	−0.829	<.001	9	view →
LIHC	Female	All	+0.676	<.001	6	view →
CHOL	All	All	+1.770	<.001	5	view →
LUSC	Male	All	+0.399	<.001	4	view →
LUAD	Female	All	−0.335	<.001	4	view →
KIRC	All	II,III,IV	−0.271	.006	4	view →
UCEC	All	All	−0.615	.007	2	view →
BLCA	All	IV	−0.494	.028	2	view →
PRAD	All	All	−0.274	.011	2	view →
STAD	Male	II,III,IV	+0.647	.020	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

NGRN–HNSC

Open the HNSC breakdown →