NGFR

Across TCGA pan-cancer cohorts, NGFR mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated NGFR data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher NGFR mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated NGFR expression acts as an unfavorable survival marker, although some lineages such as HNSC and PDAC show a favorable association.

HNSC, PDAC, and LSCC are the cancer types where NGFR mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	III,IV	1.000	0.480	.016	22	view →
PDAC	OS	Quartile	III,IV	0.938	0.171	.006	12	view →
LSCC	DFS	Median	II,III,IV	0.668	0.883	.016	6	view →
CCRCC	DFS	Quartile	II,III,IV	1.000	0.593	.006	5	view →
LUAD	OS	Median	II,III,IV	0.394	0.825	.032	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

NGFR–HNSC (DFS)

Open the HNSC breakdown →