NGFR

Across TCGA patient cohorts, NGFR mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. COAD shows the largest number of these associations.

The most reproducible NGFR-associated genes across cancer lineages are ATM, Caspase-8, and eIF4G. Each is linked with NGFR in more than 1 cancer types. Because this analysis shows association rather than direction, both NGFR-to-partner and partner-to-NGFR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by NGFR-low versus NGFR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NGFR→partner) and Y-score (partner→NGFR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.748	-2.584	<.001	.011	3	2
UCEC	Caspase-8 →	-0.274	-3.295	.019	.009	3	2
COAD	eIF4G →	-0.953	-2.991	.001	.036	3	1
COAD	Gab2 →	-0.483	-2.974	.004	.036	3	1
COAD	Ku80 →	-0.485	-2.991	.002	.036	3	1
COAD	53BP1 →	-0.747	-2.991	.001	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

ATM by NGFR expression — UCEC

Explore this box plot interactively →