NGFR

Across TCGA cell cohorts, NGFR mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible NGFR-associated genes across cancer lineages are USP17L8, TRIM43B, and GABRA6. Each is linked with NGFR in more than 1 cancer types. Because this analysis shows association rather than direction, both NGFR-to-partner and partner-to-NGFR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, USP17L8 grouped by NGFR-low versus NGFR-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NGFR→partner) and Y-score (partner→NGFR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	USP17L8 →	+0.006	+5.087	<.001	.004	3	1
LUNG_NSCLC_LUAD	TRIM43B →	+0.027	+3.857	.002	.006	3	1
LUNG_NSCLC_LUAD	GABRA6 →	+0.066	+4.189	<.001	.002	3	1
LUNG_NSCLC_LUAD	TAAR8 →	+0.013	+4.078	<.001	.009	3	1
LUNG_NSCLC_LUAD	OCSTAMP →	+0.016	+4.343	<.001	.002	3	1
LUNG_NSCLC_LUAD	GIMAP8 →	+0.016	+4.142	.002	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

USP17L8 by NGFR expression — URINARY_TRACT

Explore this box plot interactively →