NFYC

Across TCGA pan-cancer cohorts, NFYC mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated NFYC data layer compared with 19 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher NFYC mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated NFYC expression acts as an unfavorable survival marker, although some lineages such as LSCC and CCRCC show a favorable association.

LSCC, CCRCC, and LUAD are the cancer types where NFYC mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Quartile	II,III,IV	1.000	0.597	.002	46	view →
CCRCC	OS	Quartile	All	0.960	0.742	.005	22	view →
LUAD	DFS	Median	All	0.762	0.466	.001	19	view →
UCEC	DFS	Quartile	II,III,IV	0.420	0.853	.041	8	view →
PDAC	DFS	Median	III,IV	0.231	0.456	.013	5	view →
HNSC	DFS	Tertile	III,IV	0.913	0.727	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

NFYC–LSCC (OS)

Open the LSCC breakdown →