NFYC

Across TCGA pan-cancer cohorts, NFYC mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of NFYC’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where NFYC mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types NFYC is over-expressed in tumor, although a few such as HNSC and LUAD show the opposite, repressed pattern.

CCRCC, HNSC, and LSCC are the cancer types where NFYC tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NFYC mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	All	+0.242	<.001	9	view →
HNSC	All	III,IV	−0.194	.004	6	view →
LSCC	Male	II,III,IV	+0.174	<.001	5	view →
PDAC	All	All	+0.267	.004	4	view →
LUAD	Female	II,III,IV	−0.144	.031	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

NFYC–CCRCC

Open the CCRCC breakdown →