NFYC-AS1

Across TCGA pan-cancer cohorts, NFYC-AS1 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated NFYC-AS1 data layer.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher NFYC-AS1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated NFYC-AS1 expression acts as an unfavorable survival marker, although some lineages such as UCS and READ show a favorable association.

UCS, KIRC, and LGG are the cancer types where NFYC-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	OS	Median	II,III,IV	0.622	0.207	<.001	56	view →
KIRC	DFS	Quartile	II,III,IV	0.265	0.621	.002	55	view →
LGG	DFS	Median	All	0.668	0.799	<.001	41	view →
ACC	DFS	Tertile	All	0.380	0.783	<.001	33	view →
UVM	DFS	Tertile	III,IV	0.276	0.919	.001	28	view →
READ	OS	Median	II,III,IV	0.790	0.420	.013	24	view →
UCEC	DFS	Median	All	0.794	0.875	.003	24	view →
LIHC	DFS	Quartile	II,III,IV	0.233	0.478	.006	22	view →
CESC	DFS	Tertile	III,IV	0.177	0.745	.007	20	view →
HNSC	OS	Median	II,III,IV	0.454	0.283	.014	17	view →
PAAD	DFS	Median	II,III,IV	0.446	0.280	.012	16	view →
COAD	DFS	Quartile	All	0.664	0.827	.016	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

NFYC-AS1–UCS (OS)

Open the UCS breakdown →