NFYC-AS1

Across TCGA pan-cancer cohorts, NFYC-AS1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of NFYC-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where NFYC-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NFYC-AS1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

COAD, THCA, and HNSC are the cancer types where NFYC-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NFYC-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	+0.747	<.001	9	view →
THCA	Female	All	−0.465	<.001	8	view →
HNSC	All	III,IV	+0.272	.004	6	view →
CHOL	All	All	+1.376	<.001	5	view →
LIHC	All	All	+0.315	<.001	5	view →
READ	All	All	+0.535	.020	4	view →
KICH	All	All	−0.648	<.001	3	view →
LUAD	All	All	+0.414	.001	3	view →
BLCA	All	All	+0.454	.006	2	view →
LUSC	All	All	+0.310	.014	2	view →
PRAD	All	All	+0.207	.021	2	view →
KIRC	Male	All	−0.207	.038	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

NFYC-AS1–COAD

Open the COAD breakdown →