NFX1

Across TCGA patient cohorts, NFX1 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NFX1-associated genes across cancer lineages are Cyclin-B1, eIF4E, and Notch1. Each is linked with NFX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NFX1-to-partner and partner-to-NFX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by NFX1-low versus NFX1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NFX1→partner) and Y-score (partner→NFX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Cyclin-B1 →	+0.685	+2.820	.001	.035	3	2
UCEC	eIF4E →	+0.172	+2.000	.012	<.001	3	2
UCEC	Notch1 →	+0.112	+1.691	.013	.011	3	2
UCEC	p90 RSK →	+0.138	+1.700	.026	.040	3	2
UCEC	Rad50 →	-0.158	-1.459	.044	.012	3	2
SKCM	ACC1 →	+0.478	+3.012	.004	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Cyclin-B1 by NFX1 expression — SKCM

Explore this box plot interactively →