NFX1

Across TCGA pan-cancer cohorts, NFX1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of NFX1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where NFX1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NFX1 is over-expressed in tumor, although a few such as THCA and BLCA show the opposite, repressed pattern.

COAD, THCA, and LIHC are the cancer types where NFX1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NFX1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	All	+0.422	<.001	10	view →
THCA	All	II,III,IV	−0.429	<.001	8	view →
LIHC	Female	All	+0.454	<.001	6	view →
READ	Male	All	+0.450	.001	5	view →
HNSC	Male	All	+0.298	.022	4	view →
KIRC	All	All	+0.291	<.001	3	view →
KIRP	All	IV	+0.922	.027	2	view →
BLCA	Male	IV	−0.742	.012	2	view →
UCEC	All	All	−0.331	.022	2	view →
ESCA	All	II,III,IV	−0.269	.016	2	view →
CHOL	All	All	+0.741	.015	1	view →
LUSC	Female	II,III,IV	−0.475	.045	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

NFX1–COAD

Open the COAD breakdown →