NFX1

Across TCGA cell cohorts, NFX1 mutation is significantly associated with the RNA expression of many other genes, with 29 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NFX1-associated genes across cancer lineages are DEFB124, SCGB1C1, and CATSPER4. Each is linked with NFX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NFX1-to-partner and partner-to-NFX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFB124 grouped by NFX1-low versus NFX1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NFX1→partner) and Y-score (partner→NFX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	DEFB124 →	+0.111	+3.927	<.001	.004	3	1
BLOOD_Lymphoma	SCGB1C1 →	+0.115	+3.714	<.001	.006	3	1
BLOOD_Lymphoma	CATSPER4 →	+0.070	+3.736	<.001	.009	3	1
BLOOD_Lymphoma	OR52K1 →	+0.019	+5.584	<.001	<.001	3	1
BLOOD_Lymphoma	SPATS1 →	+0.748	+3.714	<.001	.006	3	1
BLOOD_Lymphoma	OR52E5 →	+0.049	+4.169	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

DEFB124 by NFX1 expression — BLOOD_Lymphoma

Explore this box plot interactively →