NFX1

Across TCGA cell cohorts, NFX1 mutation is significantly associated with the mutation status of many other genes, with 4,821 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NFX1-associated genes across cancer lineages are TP53BP1, MYH2, and DISP2. Each is linked with NFX1 in more than 3 cancer types. Because this analysis shows association rather than direction, both NFX1-to-partner and partner-to-NFX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TP53BP1 grouped by NFX1-low versus NFX1-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NFX1→partner) and Y-score (partner→NFX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	TP53BP1 →	+3.857	+4.807	.002	.002	1	4
BREAST	MYH2 →	+4.857	+4.297	.009	.009	1	4
BREAST	DISP2 →	+4.857	+4.297	.009	.009	1	4
BREAST	ACSL6 →	+4.857	+4.297	.009	.009	1	4
BLOOD_Lymphoma	BRD4 →	+3.523	+3.232	.006	.006	1	4
BLOOD_Lymphoma	FBN3 →	+2.523	+2.874	.006	.006	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,821 associations by consensus.

TP53BP1 by NFX1 expression — BREAST

Explore this box plot interactively →