NFU1

Across TCGA cell cohorts, NFU1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,774 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible NFU1-associated GO terms across cancer lineages are Regulation of DNA damage checkpoint, Potassium ion import across plasma membrane, and Positive regulation of endoplasmic reticulum tubular network organization. Each is linked with NFU1 in more than 10 cancer types. Because this analysis shows association rather than direction, both NFU1-to-partner and partner-to-NFU1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of DNA damage checkpoint grouped by NFU1-low versus NFU1-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NFU1→partner) and Y-score (partner→NFU1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Regulation of DNA damage checkpoint →	+0.072	+0.652	<.001	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	Potassium ion import across plasma membrane →	-0.144	-0.650	.006	.006	3	9
STOMACH	Positive regulation of endoplasmic reticulum tubular network organization →	+0.089	+0.770	.006	.002	3	8
UPPER_AERODIGESTIVE_TRACT	Regulation of metaphase/anaphase transition of cell cycle →	+0.092	+0.694	<.001	<.001	3	8
UPPER_AERODIGESTIVE_TRACT	Regulation of mitotic metaphase/anaphase transition →	+0.093	+0.778	<.001	<.001	3	8
UPPER_AERODIGESTIVE_TRACT	Negative regulation of chromosome segregation →	+0.129	+0.901	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,774 associations by consensus.

Regulation of DNA damage checkpoint by NFU1 expression — UPPER_AERODIGESTIVE_TRACT

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