NFU1

Across TCGA pan-cancer cohorts, NFU1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of NFU1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where NFU1 RNA is repressed in tumor relative to normal tissue. In most cancer types NFU1 is over-expressed in tumor, although a few such as KICH and BRCA show the opposite, repressed pattern.

KICH, LIHC, and KIRC are the cancer types where NFU1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NFU1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−1.747	<.001	8	view →
LIHC	Female	II,III,IV	+0.830	<.001	8	view →
KIRC	Female	III,IV	+0.472	<.001	7	view →
BRCA	All	II,III,IV	−0.363	<.001	6	view →
CHOL	All	All	+1.601	<.001	5	view →
THCA	All	All	−0.161	.011	5	view →
BLCA	Male	III,IV	−0.620	<.001	4	view →
UCEC	All	All	−0.474	.001	4	view →
HNSC	All	III,IV	+0.313	.015	3	view →
LUSC	Male	III,IV	−0.764	.029	2	view →
KIRP	All	All	−0.239	.030	2	view →
ESCA	All	All	+0.432	.035	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

NFU1–KICH

Open the KICH breakdown →