NFRKB

Across TCGA pan-cancer cohorts, NFRKB mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated NFRKB data layer compared with 22 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher NFRKB mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated NFRKB expression acts as an unfavorable survival marker, although some lineages such as LSCC and PDAC show a favorable association.

LSCC, HNSC, and PDAC are the cancer types where NFRKB mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	II,III,IV	0.865	0.516	<.001	41	view →
HNSC	OS	Median	II,III,IV	0.799	0.899	.005	15	view →
PDAC	OS	Median	III,IV	1.000	0.537	.013	13	view →
CCRCC	DFS	Quartile	III,IV	1.000	0.376	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

NFRKB–LSCC (DFS)

Open the LSCC breakdown →