NFRKB

Across TCGA pan-cancer cohorts, NFRKB RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of NFRKB’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where NFRKB RNA is repressed in tumor relative to normal tissue. In most cancer types NFRKB is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, LIHC, and KICH are the cancer types where NFRKB tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NFRKB RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	II,III,IV	−0.704	<.001	10	view →
LIHC	Female	II,III,IV	+1.155	<.001	9	view →
KICH	All	All	−0.815	<.001	7	view →
STAD	All	II,III,IV	+0.856	<.001	6	view →
BRCA	Female	All	−0.300	<.001	6	view →
CHOL	Male	All	+1.708	<.001	5	view →
HNSC	All	III,IV	+0.472	.004	5	view →
LUSC	Male	II,III,IV	+0.661	<.001	4	view →
LUAD	Male	All	+0.472	.004	3	view →
COAD	All	All	+0.179	.009	3	view →
KIRP	Male	All	−0.426	.007	2	view →
KIRP	All	IV	+0.387	.028	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

NFRKB–THCA

Open the THCA breakdown →