NFRKB

Across TCGA patient cohorts, NFRKB mutation is significantly associated with the RNA expression of many other genes, with 5,638 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NFRKB-associated genes across cancer lineages are RNPS1, CENPM, and CHEK1. Each is linked with NFRKB in more than 3 cancer types. Because this analysis shows association rather than direction, both NFRKB-to-partner and partner-to-NFRKB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNPS1 grouped by NFRKB-low versus NFRKB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NFRKB→partner) and Y-score (partner→NFRKB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNPS1 →	+0.331	+1.862	<.001	<.001	3	4
LUAD	CENPM →	+0.964	+3.584	<.001	.003	2	4
LUAD	CHEK1 →	+0.835	+3.375	.001	.004	3	3
UCEC	DONSON →	+0.566	+2.544	<.001	<.001	3	3
LUAD	RAC3 →	+1.309	+3.584	<.001	.002	3	3
LUAD	TIGD3 →	+0.495	+3.584	.008	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,638 associations by consensus.

RNPS1 by NFRKB expression — UCEC

Explore this box plot interactively →