NFRKB

Across TCGA patient cohorts, NFRKB mutation is significantly associated with the total protein of many other genes, with 57 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NFRKB-associated genes across cancer lineages are FoxM1, Annexin-1, and MSH6. Each is linked with NFRKB in more than 2 cancer types. Because this analysis shows association rather than direction, both NFRKB-to-partner and partner-to-NFRKB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by NFRKB-low versus NFRKB-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NFRKB→partner) and Y-score (partner→NFRKB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	FoxM1 →	+0.266	+2.820	.048	.035	3	3
SKCM	Annexin-1 →	+0.499	+2.321	.029	.035	3	3
COAD	MSH6 →	-0.556	-2.974	.006	.036	3	2
UCEC	p62 Lck ligand →	+0.335	+1.807	<.001	<.001	3	2
UCEC	p70-S6K →	+0.134	+1.765	.019	.011	3	2
UCEC	p90 RSK →	+0.141	+1.391	.013	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

FoxM1 by NFRKB expression — LUAD

Explore this box plot interactively →