NFRKB

Across TCGA cell cohorts, NFRKB mutation is significantly associated with the RNA expression of many other genes, with 529 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NFRKB-associated genes across cancer lineages are OR2L8, OR11H2, and OR10W1. Each is linked with NFRKB in more than 1 cancer types. Because this analysis shows association rather than direction, both NFRKB-to-partner and partner-to-NFRKB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2L8 grouped by NFRKB-low versus NFRKB-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NFRKB→partner) and Y-score (partner→NFRKB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	OR2L8 →	+0.017	+3.169	<.001	.008	3	2
LUNG_NSCLC_LUAD	OR11H2 →	+0.015	+4.481	<.001	.001	3	2
BREAST	OR10W1 →	+0.013	+5.781	<.001	.001	3	2
SKIN	REG1B →	+0.083	+4.415	<.001	.007	3	2
BLOOD_Lymphoma	IDI2 →	+0.029	+2.874	<.001	.009	3	1
BLOOD_Lymphoma	SPRR2G →	+0.209	+3.021	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 529 associations by consensus.

OR2L8 by NFRKB expression — BLOOD_Lymphoma

Explore this box plot interactively →