NFKBIE

Across TCGA cell cohorts, NFKBIE mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible NFKBIE-associated genes across cancer lineages are C6, LRRC9, and SLC7A14. Each is linked with NFKBIE in more than 1 cancer types. Because this analysis shows association rather than direction, both NFKBIE-to-partner and partner-to-NFKBIE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C6 grouped by NFKBIE-low versus NFKBIE-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NFKBIE→partner) and Y-score (partner→NFKBIE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	C6 →	+0.201	+4.922	<.001	.009	3	1
SKIN	LRRC9 →	+0.151	+3.347	<.001	.005	3	1
SKIN	SLC7A14 →	+0.666	+3.772	<.001	.003	3	1
SKIN	RIT2 →	+0.020	+4.022	<.001	.006	3	1
SKIN	OTX2 →	+0.151	+3.940	<.001	.002	3	1
SKIN	BNIP5 →	+0.021	+3.453	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

C6 by NFKBIE expression — BLOOD_Leukemia

Explore this box plot interactively →