NFKBIB

Across TCGA patient cohorts, NFKBIB mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NFKBIB-associated genes across cancer lineages are p62 Lck ligand, PKC-a, and VHL. Each is linked with NFKBIB in more than 1 cancer types. Because this analysis shows association rather than direction, both NFKBIB-to-partner and partner-to-NFKBIB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by NFKBIB-low versus NFKBIB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NFKBIB→partner) and Y-score (partner→NFKBIB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.406	+2.817	.017	.036	3	1
UCEC	PKC-a →	+0.533	+2.820	.011	.035	3	1
UCEC	VHL →	-1.145	-3.000	.001	.036	3	1
UCEC	Caspase-8 →	-0.280	-3.000	.033	.036	3	1
UCEC	IGFBP2 →	-0.883	-3.321	.009	.010	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

p62 Lck ligand by NFKBIB expression — UCEC

Explore this box plot interactively →