NFKBIB

Across TCGA pan-cancer cohorts, NFKBIB RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of NFKBIB’s most consistent transcriptional readouts.

The strongest signal is observed in stomach adenocarcinoma (STAD), where NFKBIB RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NFKBIB is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

STAD, COAD, and HNSC are the cancer types where NFKBIB tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NFKBIB RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
STAD	All	II,III,IV	+0.959	<.001	9	view →
COAD	All	II,III,IV	+0.344	.001	9	view →
HNSC	Male	All	+0.662	<.001	8	view →
LIHC	Female	II,III,IV	+0.756	<.001	7	view →
BLCA	All	All	+0.704	.001	7	view →
UCEC	All	III,IV	+0.778	<.001	6	view →
BRCA	All	All	+0.396	<.001	6	view →
LUSC	All	All	+0.464	<.001	5	view →
THCA	All	IV	−0.605	.006	4	view →
KIRC	Male	IV	+0.390	.020	4	view →
KICH	All	All	−0.388	<.001	4	view →
CHOL	All	All	+1.123	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

NFKBIB–STAD

Open the STAD breakdown →