NFKBIB

Across TCGA cell cohorts, NFKBIB mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NFKBIB-associated genes across cancer lineages are SPPL2C, OR2W5, and KRTAP22-2. Each is linked with NFKBIB in more than 1 cancer types. Because this analysis shows association rather than direction, both NFKBIB-to-partner and partner-to-NFKBIB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPPL2C grouped by NFKBIB-low versus NFKBIB-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NFKBIB→partner) and Y-score (partner→NFKBIB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	SPPL2C →	+0.150	+5.285	<.001	.003	3	1
STOMACH	OR2W5 →	+0.023	+5.285	<.001	.003	3	1
STOMACH	KRTAP22-2 →	+0.143	+5.285	<.001	.003	3	1
LARGE_INTESTINE	UTF1 →	+0.015	+3.217	<.001	.006	3	1
LARGE_INTESTINE	OR10W1 →	+0.014	+3.562	<.001	.002	3	1
LARGE_INTESTINE	GSG1L2 →	+0.011	+3.700	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

SPPL2C by NFKBIB expression — STOMACH

Explore this box plot interactively →