NFKBIB

Across TCGA cell cohorts, NFKBIB mutation is significantly associated with the mutation status of many other genes, with 4,166 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NFKBIB-associated genes across cancer lineages are PPL, ZSCAN10, and ZNF394. Each is linked with NFKBIB in more than 3 cancer types. Because this analysis shows association rather than direction, both NFKBIB-to-partner and partner-to-NFKBIB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPL grouped by NFKBIB-low versus NFKBIB-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NFKBIB→partner) and Y-score (partner→NFKBIB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PPL →	+2.799	+4.635	<.001	<.001	1	4
CNS	ZSCAN10 →	+5.044	+5.614	.003	.003	1	3
CNS	ZNF394 →	+4.459	+5.277	.005	.005	1	3
OVARY	PHF19 →	+4.977	+4.415	.007	.007	1	3
OVARY	CNKSR2 →	+4.562	+5.217	<.001	<.001	1	3
OVARY	TMC8 →	+4.977	+4.415	.007	.007	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,166 associations by consensus.

PPL by NFKBIB expression — LARGE_INTESTINE

Explore this box plot interactively →