NFIL3

Across TCGA cell cohorts, NFIL3 mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NFIL3-associated genes across cancer lineages are SPINK9, BPIFB6, and CCDC54. Each is linked with NFIL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both NFIL3-to-partner and partner-to-NFIL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPINK9 grouped by NFIL3-low versus NFIL3-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NFIL3→partner) and Y-score (partner→NFIL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	SPINK9 →	+0.057	+5.321	<.001	.005	3	2
CNS	BPIFB6 →	+0.021	+5.754	.007	.002	3	1
LARGE_INTESTINE	CCDC54 →	+0.124	+3.736	<.001	.004	3	1
LARGE_INTESTINE	OR2C1 →	+0.090	+3.578	.004	.006	3	1
LARGE_INTESTINE	WDR87 →	+0.019	+4.353	<.001	.001	3	1
LARGE_INTESTINE	INSL5 →	+0.226	+3.333	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

SPINK9 by NFIL3 expression — CNS

Explore this box plot interactively →