NFIB

Across TCGA patient cohorts, NFIB protein abundance is significantly associated with the RNA expression of many other genes, with 18,807 significant associations in total. GBM shows the largest number of these associations.

The most reproducible NFIB-associated genes across cancer lineages are ADGRB3, FXYD6, and GPM6A. Each is linked with NFIB in more than 5 cancer types. Because this analysis shows association rather than direction, both NFIB-to-partner and partner-to-NFIB results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NFIB versus ADGRB3 in GBM, with a Pearson correlation of 0.41.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NFIB→partner) and Y-score (partner→NFIB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ADGRB3 →	+1.307	+0.654	<.001	<.001	3	6
GBM	FXYD6 →	+1.428	+0.667	<.001	<.001	3	6
GBM	GPM6A →	+1.275	+0.631	<.001	<.001	3	6
HNSC	PSIP1 →	+0.784	+0.757	<.001	<.001	3	6
UCEC	GGT7 →	+0.766	+0.473	<.001	<.001	3	5
UCEC	FBLN5 →	+1.120	+0.520	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,807 associations by consensus.

NFIB vs ADGRB3 — GBM

Explore this scatter interactively →