NFIB

Across TCGA pan-cancer cohorts, NFIB RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of NFIB’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where NFIB RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NFIB is over-expressed in tumor, although a few such as BLCA and LUSC show the opposite, repressed pattern.

KIRC, BLCA, and LUSC are the cancer types where NFIB tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NFIB RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+0.802	<.001	11	view →
BLCA	Male	IV	−2.530	<.001	8	view →
LUSC	All	II,III,IV	−1.078	<.001	8	view →
KICH	Female	All	−0.960	<.001	7	view →
BRCA	All	III,IV	−2.394	<.001	6	view →
LUAD	Female	III,IV	−1.105	<.001	6	view →
CHOL	All	All	+1.573	<.001	3	view →
LIHC	All	All	+0.390	.006	3	view →
UCEC	All	All	−0.909	.014	2	view →
READ	Female	All	−0.749	.028	2	view →
KIRP	All	All	+0.483	.005	2	view →
PRAD	All	All	+0.201	.037	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

NFIB–KIRC

Open the KIRC breakdown →