NFIB

Across TCGA patient cohorts, NFIB mutation is significantly associated with the RNA expression of many other genes, with 5,417 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NFIB-associated genes across cancer lineages are PSME2P5, MTND4P33, and TRBVB. Each is linked with NFIB in more than 1 cancer types. Because this analysis shows association rather than direction, both NFIB-to-partner and partner-to-NFIB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PSME2P5 grouped by NFIB-low versus NFIB-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NFIB→partner) and Y-score (partner→NFIB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PSME2P5 →	+0.310	+3.110	.001	.002	3	2
COAD	MTND4P33 →	+0.072	+4.122	<.001	.001	3	2
SKCM	TRBVB →	+0.563	+5.970	<.001	.002	3	2
CESC	RPS4Y2 →	+0.034	+3.089	<.001	.004	3	2
UCEC	ALDOA →	+0.507	+2.209	<.001	<.001	3	2
UCEC	ATP5F1A →	+0.400	+1.470	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,417 associations by consensus.

PSME2P5 by NFIB expression — COAD

Explore this box plot interactively →