NFIB

Across TCGA patient cohorts, NFIB mutation is significantly associated with the total protein of many other genes, with 62 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NFIB-associated genes across cancer lineages are Caspase-7-cleavedD198, ATM, and Bak. Each is linked with NFIB in more than 2 cancer types. Because this analysis shows association rather than direction, both NFIB-to-partner and partner-to-NFIB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by NFIB-low versus NFIB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NFIB→partner) and Y-score (partner→NFIB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.394	+1.415	.019	.040	3	3
UCEC	ATM →	-0.615	-2.000	<.001	<.001	3	2
UCEC	Bak →	+0.159	+1.321	.026	.027	3	2
UCEC	14-3-3_beta →	-0.093	-2.221	.001	.001	3	1
UCEC	eEF2 →	+0.306	+2.087	.002	.004	3	1
UCEC	EGFR_pY1068 →	-0.238	-2.169	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 62 associations by consensus.

Caspase-7-cleavedD198 by NFIB expression — UCEC

Explore this box plot interactively →