NFIB

Across TCGA cell cohorts, NFIB mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NFIB-associated genes across cancer lineages are NPY2R, C3orf85, and LYZL1. Each is linked with NFIB in more than 1 cancer types. Because this analysis shows association rather than direction, both NFIB-to-partner and partner-to-NFIB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NPY2R grouped by NFIB-low versus NFIB-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NFIB→partner) and Y-score (partner→NFIB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	NPY2R →	+0.126	+5.539	<.001	.003	3	1
BLOOD_Leukemia	C3orf85 →	+0.025	+5.539	.004	.003	3	1
LUNG_NSCLC_LUAD	LYZL1 →	+0.027	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	KRTAP5-11 →	+0.080	+4.887	<.001	.009	3	1
LARGE_INTESTINE	MSGN1 →	+0.082	+3.345	<.001	.007	3	1
LARGE_INTESTINE	LMNTD1 →	+0.212	+3.554	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

NPY2R by NFIB expression — BLOOD_Leukemia

Explore this box plot interactively →