NFE2L3

Across TCGA cell cohorts, NFE2L3 mutation is significantly associated with the RNA expression of many other genes, with 33 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NFE2L3-associated genes across cancer lineages are MTNR1B, WFDC11, and RXFP2. Each is linked with NFE2L3 in more than 1 cancer types. Because this analysis shows association rather than direction, both NFE2L3-to-partner and partner-to-NFE2L3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTNR1B grouped by NFE2L3-low versus NFE2L3-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NFE2L3→partner) and Y-score (partner→NFE2L3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	MTNR1B →	+0.015	+4.754	<.001	<.001	3	2
BLOOD_Myeloma	WFDC11 →	+0.112	+4.754	<.001	<.001	3	1
BREAST	RXFP2 →	+0.023	+4.672	<.001	.002	3	1
BREAST	SSX5 →	+0.091	+4.672	<.001	.002	3	1
BREAST	MS4A13 →	+0.116	+5.312	<.001	<.001	3	1
STOMACH	TRIM49D2 →	+0.030	+4.285	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

MTNR1B by NFE2L3 expression — BLOOD_Myeloma

Explore this box plot interactively →