NFATC2

Across TCGA patient cohorts, NFATC2 mutation is significantly associated with the RNA expression of many other genes, with 5,560 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NFATC2-associated genes across cancer lineages are CENPU, TYW3, and TK1. Each is linked with NFATC2 in more than 4 cancer types. Because this analysis shows association rather than direction, both NFATC2-to-partner and partner-to-NFATC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CENPU grouped by NFATC2-low versus NFATC2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NFATC2→partner) and Y-score (partner→NFATC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CENPU →	+0.519	+1.447	.001	.001	3	4
UCEC	TYW3 →	+0.371	+2.043	<.001	.001	3	4
UCEC	TK1 →	+0.525	+3.108	<.001	<.001	3	4
UCEC	CX3CR1 →	-0.415	-1.393	.002	.002	3	4
UCEC	BIRC5 →	+0.681	+2.392	<.001	<.001	3	4
UCEC	RANBP1 →	+0.410	+1.954	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,560 associations by consensus.

CENPU by NFATC2 expression — UCEC

Explore this box plot interactively →