NFATC2

Across TCGA pan-cancer cohorts, NFATC2 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated NFATC2 data layer compared with 10 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher NFATC2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated NFATC2 expression acts as an unfavorable survival marker, although some lineages such as LUAD and BRCA show a favorable association.

UVM, LUAD, and BRCA are the cancer types where NFATC2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Quartile	All	0.326	0.748	<.001	96	view →
LUAD	OS	Median	All	0.752	0.622	<.001	87	view →
BRCA	DFS	Tertile	III,IV	0.937	0.806	.004	59	view →
LGG	OS	Tertile	All	0.369	0.551	<.001	46	view →
KICH	DFS	Tertile	III,IV	0.285	1.000	.007	38	view →
HNSC	DFS	Quartile	All	0.742	0.611	.003	37	view →
KIRP	OS	Median	All	0.903	0.960	.009	25	view →
LIHC	DFS	Quartile	All	0.222	0.474	.004	24	view →
SKCM	OS	Quartile	All	0.453	0.254	.003	23	view →
KIRC	DFS	Quartile	III,IV	0.771	0.487	.018	18	view →
READ	OS	Tertile	IV	1.000	0.621	.024	11	view →
SCLC	OS	Median	II,III,IV	0.585	0.273	.009	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

NFATC2–UVM (DFS)

Open the UVM breakdown →