NFATC2

Across TCGA cell cohorts, NFATC2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,497 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible NFATC2-associated GO terms across cancer lineages are Negative regulation of vascular associated smooth muscle cell differentiation, Regulation of early endosome to late endosome transport, and Mucosal immune response. Each is linked with NFATC2 in more than 7 cancer types. Because this analysis shows association rather than direction, both NFATC2-to-partner and partner-to-NFATC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of vascular associated smooth muscle cell differentiation grouped by NFATC2-low versus NFATC2-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NFATC2→partner) and Y-score (partner→NFATC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Negative regulation of vascular associated smooth muscle cell differentiation →	-0.166	-1.076	<.001	<.001	3	8
CNS	Regulation of early endosome to late endosome transport →	+0.074	+0.932	<.001	<.001	3	7
LUNG_SCLC	Mucosal immune response →	-0.142	-1.255	.003	.006	3	7
SKIN	IRE1-mediated unfolded protein response →	+0.075	+1.399	.002	.009	3	7
OESOPHAGUS	Leukemia inhibitory factor signaling pathway →	+0.189	+1.549	<.001	<.001	3	7
SKIN	Elastin metabolic process →	+0.089	+1.997	.002	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,497 associations by consensus.

Negative regulation of vascular associated smooth muscle cell differentiation by NFATC2 expression — BREAST

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