NFATC2

Across TCGA cell cohorts, NFATC2 mutation is significantly associated with the RNA expression of many other genes, with 1,567 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NFATC2-associated genes across cancer lineages are PPP6R2, MLC1, and ATP1A3. Each is linked with NFATC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NFATC2-to-partner and partner-to-NFATC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPP6R2 grouped by NFATC2-low versus NFATC2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NFATC2→partner) and Y-score (partner→NFATC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PPP6R2 →	+0.507	+3.411	.004	.003	3	2
BLOOD_Leukemia	MLC1 →	-2.468	-3.292	.002	.007	3	2
BLOOD_Leukemia	ATP1A3 →	+1.878	+3.351	.003	.003	3	2
BLOOD_Leukemia	TTK →	+0.853	+3.366	<.001	.002	3	2
BLOOD_Leukemia	RLF →	+0.887	+3.351	<.001	.003	3	2
BLOOD_Leukemia	CASP8AP2 →	+0.622	+3.351	.008	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,567 associations by consensus.

PPP6R2 by NFATC2 expression — BLOOD_Leukemia

Explore this box plot interactively →