Across TCGA pan-cancer cohorts, NF2 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated NF2 data layer compared with 18 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher NF2 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated NF2 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUAD show a favorable association.

PDAC, CCRCC, and UCEC are the cancer types where NF2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Tertile	II,III,IV	0.404	0.681	.018	12	view →
CCRCC	DFS	Median	III,IV	0.809	1.000	.012	11	view →
UCEC	OS	Tertile	All	0.968	0.831	.026	4	view →
LUAD	OS	Median	All	0.997	0.925	.015	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: NF2 tumor-vs-normal RNA expression · all NF2 data types