Across TCGA patient cohorts, NF2 RNA expression is significantly associated with the mutation status of many other genes, with 11,823 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NF2-associated genes across cancer lineages are TP53, VPS13B, and MACF1. Each is linked with NF2 in more than 7 cancer types. Because this analysis shows association rather than direction, both NF2-to-partner and partner-to-NF2 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NF2→partner) and Y-score (partner→NF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TP53 →	+0.814	+0.190	<.001	<.001	3	8
COAD	VPS13B →	+1.876	+0.276	.001	.001	3	5
READ	MACF1 →	+3.188	+0.425	.009	.007	2	5
COAD	CIC →	+2.100	+0.371	.003	<.001	3	4
COAD	FAM135B →	+3.539	+0.325	.002	.002	3	4
COAD	NCOR1 →	+2.150	+0.339	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,823 associations by consensus.

Exploration

NF2 survival (RNA) · tumor vs normal (RNA) · all NF2 data types