Across TCGA patient cohorts, NF2 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NF2-associated genes across cancer lineages are MSH6, mTOR_pS2448, and ATM. Each is linked with NF2 in more than 2 cancer types. Because this analysis shows association rather than direction, both NF2-to-partner and partner-to-NF2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NF2→partner) and Y-score (partner→NF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH6 →	-0.451	-2.700	<.001	.005	3	3
UCEC	mTOR_pS2448 →	-0.118	-1.680	.028	.042	3	3
UCEC	ATM →	-0.653	-3.000	<.001	<.001	3	3
UCEC	PDCD4 →	-0.540	-2.115	.001	.016	3	2
UCEC	Annexin-1 →	+0.551	+2.242	.003	.005	3	2
UCEC	STAT3_pY705 →	-0.316	-2.115	<.001	.016	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Exploration

NF2 survival (RNA) · tumor vs normal (RNA) · all NF2 data types