Across TCGA cell cohorts, NF2 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,470 significant associations in total. BONE shows the largest number of these associations.

The most reproducible NF2-associated GO terms across cancer lineages are Regulation of protein localization to early endosome, Positive regulation of protein localization to early endosome, and Positive regulation of early endosome to late endosome transport. Each is linked with NF2 in more than 14 cancer types. Because this analysis shows association rather than direction, both NF2-to-partner and partner-to-NF2 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NF2→partner) and Y-score (partner→NF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Regulation of protein localization to early endosome →	+0.211	+1.371	.001	.003	3	15
LIVER	Positive regulation of protein localization to early endosome →	+0.211	+1.371	.001	.003	3	15
BONE	Positive regulation of early endosome to late endosome transport →	+0.173	+1.457	<.001	<.001	3	15
BONE	Positive regulation of actin filament bundle assembly →	+0.194	+1.294	<.001	<.001	3	15
BREAST	Regulation of early endosome to late endosome transport →	+0.175	+1.659	<.001	<.001	3	14
KIDNEY	Caveolin-mediated endocytosis →	+0.216	+1.483	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,470 associations by consensus.

Exploration

NF2 survival (RNA) · tumor vs normal (RNA) · all NF2 data types