Across TCGA cell cohorts, NF2 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NF2-associated genes across cancer lineages are USP17L17, PPP1R2C, and PPY. Each is linked with NF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NF2-to-partner and partner-to-NF2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NF2→partner) and Y-score (partner→NF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	USP17L17 →	+0.013	+5.285	<.001	.003	3	1
OVARY	PPP1R2C →	+0.043	+4.450	<.001	.004	3	1
OVARY	PPY →	+0.198	+4.029	<.001	.009	3	1
OVARY	XCL2 →	+0.105	+4.450	<.001	.004	3	1
OVARY	LCE3E →	+0.033	+4.990	.005	.001	3	1
BLOOD_Lymphoma	C1orf87 →	+0.021	+4.867	.008	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Exploration

NF2 survival (RNA) · tumor vs normal (RNA) · all NF2 data types