Across TCGA patient cohorts, NF1 RNA expression is significantly associated with the protein abundance of many other proteins, with 21,021 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible NF1-associated proteins across cancer lineages are ZNF830, CAMSAP2, and LIG3. Each is linked with NF1 in more than 5 cancer types. Because this analysis shows association rather than direction, both NF1-to-partner and partner-to-NF1 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (NF1→partner) and Y-score (partner→NF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ZNF830 →	+0.362	+0.567	<.001	<.001	3	6
LSCC	CAMSAP2 →	+0.279	+0.464	.001	<.001	3	6
LSCC	LIG3 →	+0.580	+0.774	<.001	<.001	3	6
GBM	PLCG2 →	-0.561	-0.559	<.001	<.001	3	6
LSCC	TXNDC5 →	-0.450	-0.451	<.001	<.001	3	5
GBM	SAE1 →	+0.392	+0.562	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 21,021 associations by consensus.

Exploration

NF1 survival (RNA) · tumor vs normal (RNA) · all NF1 data types