Across TCGA patient cohorts, NF1 protein abundance is significantly associated with the RNA expression of many other genes, with 10,852 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible NF1-associated genes across cancer lineages are C17orf75, RHOT1, and BLMH. Each is linked with NF1 in more than 5 cancer types. Because this analysis shows association rather than direction, both NF1-to-partner and partner-to-NF1 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NF1→partner) and Y-score (partner→NF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	C17orf75 →	+0.775	+0.337	<.001	<.001	3	6
HNSC	RHOT1 →	+0.787	+0.321	.002	<.001	3	6
LSCC	BLMH →	+0.642	+0.273	<.001	<.001	3	5
LSCC	TEFM →	+0.470	+0.317	<.001	<.001	3	5
BRCA	LRRC37BP1 →	+0.478	+0.296	<.001	<.001	3	5
BRCA	TADA2A →	+0.647	+0.335	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,852 associations by consensus.

Exploration

NF1 survival (RNA) · tumor vs normal (RNA) · all NF1 data types