Across TCGA patient cohorts, NF1 protein abundance is significantly associated with the protein abundance of many other proteins, with 16,639 significant associations in total. GBM shows the largest number of these associations.

The most reproducible NF1-associated proteins across cancer lineages are NF1_S2543, NF1_S2597, and NF1_T2565. Each is linked with NF1 in more than 8 cancer types. Because this analysis shows association rather than direction, both NF1-to-partner and partner-to-NF1 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (NF1→partner) and Y-score (partner→NF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	NF1_S2543 →	+0.709	+0.421	<.001	<.001	3	9
BRCA	NF1_S2597 →	+0.742	+0.297	<.001	<.001	3	9
GBM	NF1_T2565 →	+0.842	+0.559	<.001	<.001	3	8
LUAD	NF1_S2523 →	+0.540	+0.269	<.001	<.001	3	7
BRCA	LCP1 →	-0.701	-0.419	<.001	<.001	3	6
UCEC	MYDGF →	-0.473	-0.350	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,639 associations by consensus.

Exploration

NF1 survival (RNA) · tumor vs normal (RNA) · all NF1 data types