Across TCGA patient cohorts, NF1 mutation is significantly associated with the RNA expression of many other genes, with 8,128 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NF1-associated genes across cancer lineages are TCF19, KIF11, and CDC37. Each is linked with NF1 in more than 5 cancer types. Because this analysis shows association rather than direction, both NF1-to-partner and partner-to-NF1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NF1→partner) and Y-score (partner→NF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LGG	TCF19 →	+1.104	+3.708	<.001	<.001	3	6
LGG	KIF11 →	+0.895	+3.467	.001	.002	3	6
UCEC	CDC37 →	+0.221	+1.357	.003	<.001	3	6
LGG	CDCA2 →	+1.091	+3.711	<.001	<.001	3	5
LGG	WDHD1 →	+0.711	+2.630	<.001	.005	3	5
LGG	NCAPG →	+1.263	+3.367	<.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,128 associations by consensus.

Exploration

NF1 survival (RNA) · tumor vs normal (RNA) · all NF1 data types