Across TCGA patient cohorts, NF1 mutation is significantly associated with the total protein of many other genes, with 121 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NF1-associated genes across cancer lineages are ASNS, C-Raf, and p38-MAPK_pT180_Y182. Each is linked with NF1 in more than 4 cancer types. Because this analysis shows association rather than direction, both NF1-to-partner and partner-to-NF1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NF1→partner) and Y-score (partner→NF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ASNS →	+0.670	+1.874	<.001	.049	3	5
LGG	C-Raf →	+0.184	+2.356	.006	.019	3	5
STAD	p38-MAPK_pT180_Y182 →	-0.360	-3.149	.019	.017	3	4
COAD	c-Kit →	-0.542	-1.991	.026	.031	3	4
LGG	S6_pS240_S244 →	+0.471	+2.342	<.001	.019	3	4
BLCA	MIG-6 →	+0.133	+2.334	.002	.018	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 121 associations by consensus.

Exploration

NF1 survival (RNA) · tumor vs normal (RNA) · all NF1 data types