NEXN

Across TCGA patient cohorts, NEXN mutation is significantly associated with the RNA expression of many other genes, with 5,312 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NEXN-associated genes across cancer lineages are AURKB, ATP5F1B, and TIMELESS. Each is linked with NEXN in more than 2 cancer types. Because this analysis shows association rather than direction, both NEXN-to-partner and partner-to-NEXN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AURKB grouped by NEXN-low versus NEXN-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEXN→partner) and Y-score (partner→NEXN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	AURKB →	+0.983	+3.341	<.001	.005	3	3
UCEC	ATP5F1B →	+0.457	+1.680	.001	<.001	3	3
UCEC	TIMELESS →	+0.607	+1.857	<.001	<.001	3	3
UCEC	PIMREG →	+1.014	+3.065	<.001	<.001	3	3
UCEC	TYMS →	+0.985	+2.678	<.001	<.001	3	3
COAD	PKM →	+0.501	+3.509	.004	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,312 associations by consensus.

AURKB by NEXN expression — SKCM

Explore this box plot interactively →